শুক্রবার, ৩০ নভেম্বর, ২০১২

Eye Doctors Altering Eyeglasses Prescription Evert Time Causing ...

Eye Doctors Altering Eyeglasses Prescription Evert Time Causing You To Concerned About Eyes & Blindness

A generally heard question during my eye doctor eye care center is will my eyeglasses prescription keep altering? Adopted frequently by am i going to go blind? The second is a very common misperception based a little on fact. People due lose eyesight and suffer lack of vision from degenerative myopia or nearsightedness. There?s a substantial rise in the proportion of people that get retinal detachments within the nearsighted population. However, despite the fact that this can be a significant increase, relatively speaking it?s very rare. A really small segment from the population will have degenerative nearsightedness. This can be a pathological condition from the eye where it progressively will get worse in a rapid rate and results in numerous serious vision problems including retinal detachments, glaucoma, cataracts and retinal degeneration that induce blindness. This problem is apparent in adolescence and when you need to request you do not have it.

Degenerative myopia includes a reported incidence of twoPercent within the U . s . States, and it is the seventh leading reason for blindness. It?s more prevalent in Chinese, Jewish, Japanese and Arab populations, and ladies. During my patient population the incidence is a lot lower, most likely under .02%. It most likely has some reliance on how pathological myopia is determined, if it?s not sight threatening or lowering vision I do not classify it as being pathological nearsightedness. Progressive myopia is connected with a few systemic illnesses like Marfan?s syndrome (most likely what Abraham Lincoln subsequently had), retinopathy of prematurity, Ehler?s-Danlos syndrome, and albinism. You?d most likely know should you have had these conditions. The in degenerative myopia are usually excessive while very young that they?re most likely 5-10 x worse than you presently experience. Everything being stated, when will your vision quit altering?

Personally In my opinion all the research is outdated. Years back whenever a child arrived at adolescence the eyeglass prescription stable. The periods of rapid body growth appeared to correlate fairly well with eye growth. The time of change has progressively extended in time. First you need to define what stable means. With a, this means a big change of four steps which in optical terminology is a diopter. Past research has indicated myopia evolves within 20% of individuals older than 20 who return to school (or reside in restricted near conditions like submarines). Should you decide 3 steps is change rather than 4 this number rises to in excess of 40%. Define it as being 2 steps or less each year (.50 diopters) and also the amounts go even greater.

The main one factor that?s indisputable today is the fact that blurred vision is really a stimulus for alternation in your glasses prescription. What?s not obvious (pardon the pun), is exactly what this really means. Under focusing, over focusing, fluctuations in focusing may all cause blurred vision. It might take seconds or hrs to begin the procedure. Current research signifies it?s not central vision but peripheral blurred vision that could cause visual changes. In the studies of alterations in vision in older students it?s obvious in my experience that you will find genetic and environment factors at the office. Authors of some studies don?t even think the study substantiates an environment factor, only age start of myopia-I disagree. Things I believe is the world is tremendously altering right into a near centered atmosphere (i.e. all of us live on the web where you stand now). This isn?t an ordinary visual atmosphere and most likely not the best for that eyes (computer vision syndrome is around the upswing). The choice is quickly becoming unemployment within our computer dependent work conditions so almost all a choice. Maybe whenever you gaze in the computer for 3 hrs take a look up a focusing spasm happens for thirty seconds and also the blurred image causes your visual system to adapt (focus for the best distance). This mal-adaptation would cause myopia. On the other hand you can habitually focus to shut or too much (normal is a touch behind the item seen).

Most likely it?s something altogether different. Concentrating on a set plane if we are made to concentrate a three dimensional world could push the attention into altering. The tear film layer from the eye is vital for obvious vision and dry eyes might cause blurred vision. Focusing on a pc causes home loan business blink rate and subsequent drying out from the eye and degradation from the tear film layer. An undesirable tear film equals fuzzy vision and perhaps Dry Eye Syndrome ( DES). Regardless, the end result In my opinion, (without any real evidence to support it apart from things i see daily and year upon year), is the fact that very couple of people totally stabilize today at all ages. Most show a really marked decrease in changes about 20, particularly when they get free from school. Lots of opticians refer ?stable? as eyeglass correction changes 2 steps or less each year.

A couple of patients I see start getting better without no reason. I?ve requested the questions I?m able to think about about lifestyle etc. and also the only common factor I?ve ever found is almost always they?re putting on their full distance correction, not under remedied like some Eye Doctors believe is advantageous. Please be aware that merely a small subgroup of individuals putting on their full RX improve year upon year. The attention includes a built-in self fixing mechanism known as emmetropization that we believe begins working again in many people in a later age for unknown reasons. When we did not obtain that process there?d be lots of very, very thick contacts! In Addition, I see a smaller amount dramatic variations in medications between your eyes when individuals put on their glasses full-time.

From time to time people have a similar prescription both in eyes and request whether it will remain this way-most likely not but putting on the right lens prescription could keep them much nearer to one another. Statistically nearsightedness decreases just a little inside your 40?s because of alterations in the lens within the eye. Later in existence, the lens changes again as cataracts begin to develop and nearsightedness increases. This is actually nice for individuals which are farsighted given that they notice enhancements (a minimum of for some time). Those who are diabetic with poorly controlled bloodstream sugar have prescription changes all around the board.

Finally, patients request whether they can do anything whatsoever to avoid their eyes from altering. The reply is??Maybe-not-or certainly yes later on. A prescription medication going to be out within the next couple of years may slow alterations in kids eyes. Orhtokeratology (also known as cornael molding in certain formats) may slow changes but this requires putting on rigid gas permeable contacts and often comfort issues. One soft contact that is less ?elastic? than the others may slow changes. Aspheric soft contact contacts might have some potential for me but there?s no grounds for this presently that i?m conscious of. One small study indicated bifocal soft contact contacts could also possess some effect, again my prediction is because of an aspheric impact on peripheral vision correction. We always recommend good ergonomics if perhaps for that relief of eyestrain they provide: Lookup every fifteen minutes approximately at something far then close and back and alternate 10 occasions to interrupt any focusing spasms. Wake up every hour even when you simply walk round the computer-this breaks the physical and visual posture. Use anti reflection films in your glasses prescription and also have a separate computer lens prescription if you?re presbyopic (need bifocals). An unpreserved artificial tear used 3-4x each day when you are performing lots of near work might be useful. Children who?re esophoric (eyes that do not submit but possess the inclination to show in at near) will benefit from the multifocal prescription. I?d think this is also true of grown ups however I?m not conscious of any research. It most likely can change again sooner or later later on. Dietary advice varies everywhere and most likely comes with an effect- eat a healthy diet plan with a lot of fruits and vegetable and little sugar is all about so far as I?m able to say at this time around. And be assured, your odds of going blind despite the fact that how well you see appears to alter each year is extremely, really low-to see your optometrist each year for any dilated eye exam is excellent preventative care.

Source: http://www.tcob1.net/eye-doctors-altering-eyeglasses-prescription-evert-time-causing-you-to/

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U.S. Drug Czar on Legal Pot in Colorado and Washington: It's "very ...

Drug Czar Gil Kerlikowske went on American Public Media's Marketplace Thursday to respond to the legalization of recreational marijuana in Colorado and Washington state.?

"What really troubles me," Kerlikowske said, "is that in Washington state, which really prides itself on independence, it was $6 million of outside money that was raised in order to advocate for legalization. Pretty hard to compete against $6 million in outside money."?

(Kerlikowske is right that a lot of outside money went into funding Washington state's legalization campaign. But it wasn't all outside money, and it wasn't all big dollar contributions, as I detailed in The New Republic.)?

Interviewer?Kai Ryssdal then asks Kerlikowske about the "change of heart" the Obama administration seems to have had about medical marijuana. "The president came in saying, in essence, 'We have better things to do with our time.' Now in the last two years, there has been more vigorous enforcement of drug control laws."?

Kerlikowske's response is that the federal government said it would not go after medical marijuana users, and has in fact not gone after them. But?"there has been nothing that I have seen or heard from the Department of Justice that says 'Look we're not going to continue to enforce federal law,'" Kerlikowske said of medical marijuana growers and sellers. "And we're going to continue to take a hard look at those people who are involved in making money on essentially a violation of federal law."

Ryssdal then asks Kerlikowske the question on every drug reformer's lips: Will Washington crack down on legal pot in Colorado and Washington?

"There are questions in front of the Department of Justice," Kerlikowske said. "They've made some statements, and it has been very clear that federal law will continue to be enforced. And I think we'll wait and see what those decisions are from the attorney general and the Department of Justice." (Listen to the full interview here.)

Yesterday, Secretary of State Hillary Clinton said this about Colorado and Washington:?"This is an ongoing debate. We are formulating our own response to the votes of two of our states as you know ??what that means for the federal system, the federal laws and law enforcement."

Source: http://reason.com/blog/2012/11/30/us-drug-czar-on-legal-pot-in-colorado-an

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Exceptional Buys Ranger To Give A Monitoring Shot In The Arm To Its ?DevOps? Platform

163941v1-max-250x250There is some consolidation in the error-tracking/monitoring space.?Exceptional, the error-tracking service for cloud developers, has announced the acquisition of the Ranger monitoring service to extend the U.S. company's 'DevOps' platform. Terms of the deal remain undisclosed, although Exceptional CEO Jonathan Siegel tells me it's a "solid six-figure purchase," and covers the Ranger product (which has just been updated to version 2.0) and existing customer base-only.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/U2P29I6BJd8/

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Epic Mickey 2: The Power Of Two Review | Video Game Blog, Video ...

[unable to retrieve full-text content]The first Epic Mickey game, released exclusively on Wii, was a really nice surprise. Ever since the first concept artwork was unveiled we knew that the game was set to be different from the usual Disney themed game: it was a ...

Source: http://gamersyndrome.com/2012/videogame-reviews/epic-mickey-2-the-power-of-two-review/

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Allan Vella, President and CEO of the Fox Theatre, to be a Keynote ...

[unable to retrieve full-text content]28, 2012) ? Paciolan, an industry-leading provider of ticketing, marketing, and fundraising solutions to more than 500 live entertainment organizations, including performing arts venues, announced today that Allan Vella, ...

Source: http://paciolan.com/2012/hot-topics/allan-vella-president-and-ceo-of-the-fox-theatre-to-be-a-keynote-speaker-at-pacnet-13-conference/

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Sports Car Insurance ? Lower Your Auto Insurance | Sport Cars ...

Sports car insurance premiums seem to continually get higher. There are a lot of factors to cause your car insurance rates to increase, but did you know there are things you need to do to be sure you are getting a good rate on sports car policies?

Many times people wonder why classic autos and vintage autos insurance premiums are high just like cars that have the big fast engines like what you see in corvettes or other fast sports cars. The bottom line is insurance actuaries calculate the insurance rates and if you want to get the best deal on your insurance you have to know how insurance companies think.

It is obvious that you get insurance to protect your car and you do not want just any insurance, you want good auto insurance because your car is special. But you also want to balance getting coverage you want at affordable prices.

So if you are a sports car driver and you want to get good insurance then here a few things you need to consider.

First, if you have multiple policies with the same company you can many times get a multi-policy discount. You probably have the coverage for your house or apartment already so it is simple to make sure you have it with the same company that is covering your sports vehicle and this can lower your auto insurance rates.

Another tip to lower your premiums is to ask to have your liability and collision coverage suspended in the winter time if you are not driving your sports car. Now this is said with a big caution. You can not drive your car while the coverage is suspended and if you do then your insurance will not pay for a claim. But this tip can reduce your out of pocket insurance premiums.

Still yet another tip to make your car insurance rates easier on your wallet is to use the excuse of your high insurance rates to negotiate a lower car price. In other words the money is coming out of your pocket to pay for your sports car as well as to pay for your sports car insurance premiums so the car sales person knows you will have to pay high premiums so use this fact to get the dealership to give you a better price. If the dealership wants to earn your business then they will move on their price.

A final tip to help you if you are thinking of buying a sports car and if you are shopping for insurance is to be sure you have a good driving record. If you have tickets your insurance premiums will be high. To be sure to get the best deal you really need to have a clean driving record. There are some companies that specialize in different types of auto insurance including, but not limited to getting classical car insurance, historical auto insurance, and of course sports car insurance.

Get Quotes Online.

Source: http://www.laveudelespanyolista.com/387-sports-car-insurance-lower-your-auto-insurance.html

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বৃহস্পতিবার, ২৯ নভেম্বর, ২০১২

How climate change could affect entire forest ecosystems

ScienceDaily (Nov. 28, 2012) ? The fog comes in, and a drop of water forms on a pine needle, rolls down the needle, and falls to the forest floor. The process is repeated over and over, on each pine needle of every tree in a forest of Bishop pines on Santa Cruz Island, off the coast of Santa Barbara. That fog drip helps the entire forest ecosystem stay alive.

Thousands of years ago, in cooler and wetter times, Bishop pine trees are thought to have proliferated along the West Coast of the U.S. and Mexico. Now, stratus clouds -- the low-altitude clouds known locally as "June gloom" -- help keep the trees growing on Santa Cruz Island, Santa Rosa Island, and on one island off Baja California. Other than these locations, Bishop pine trees grow only farther north in California where it is cooler and wetter.

Mariah S. Carbone, first author of a new paper, titled "Cloud Shading and Fog Drip Influence the Metabolism of a Coastal Pine Ecosystem," and her co-authors, studied the influence of clouds on the largest Bishop pine forest of Santa Cruz Island. Carbone is a postdoctoral fellow with UC Santa Barbara's National Center for Ecological Analysis and Synthesis (NCEAS). Their study was published in the journal Global Change Biology.

"When people think about climate change, they're often thinking about temperature and precipitation," said Carbone. "When you think about precipitation, it's rain and snow, depending on where you are. What this study showed is that you can have really important water inputs coming from clouds that influence the carbon cycle."

She explained that clouds are one of the largest uncertainties in global climate, and that the forest ecosystem interactions with clouds have a large impact -- one that has rarely been studied before, particularly in Southern California.

Changes in cloudiness or cloud height with global warming will alter the types of forest ecosystems that grow in coastal California, explained Carbone. While predictions about how rainfall will change in California over the next 50 years are uncertain, fog and low-stratus clouds might decline as sea-surface temperatures warm. Like the relict Bishop pines on Santa Cruz Island, and the majestic coastal Redwood forests in Northern California, forests remove and store carbon from the atmosphere, and thus are important for understanding greenhouse gas concentrations in the future. These coastal forests are also highly valued for their aesthetic and recreation qualities.

Fog is often present in coastal California during May through August. It occurs when the land warms in the spring and summer, and moist ocean air is pulled over cold, upwelling coastal waters. This moist air then condenses under a stable atmospheric inversion layer, creating low clouds or fog banks.

"The finding that summer fog strongly impacts carbon cycling highlights the need for improved understanding of whether we should expect coastal summer cloud behavior to change in a warmer world," said second author A. Park Williams, a former graduate student in UCSB's Geography Department, now at Los Alamos National Laboratory. "A change in summer fogginess could produce temperature, moisture, and carbon feedbacks in coastal ecosystems that easily swamp out the effects expected from increased greenhouse gases alone," said Williams.

The carbon cycle involves the movement of billions of tons of carbon between the oceans, lands, and atmosphere every year. Increased amounts of carbon dioxide, a potent greenhouse gas, ??are injected into the atmosphere and contribute to climate change.

The scientists received help from NASA and NOAA in collecting information. "We used satellite data to map the spatial distribution of cloud cover across the western portion of Santa Cruz Island," said senior author Christopher J. Still, formerly an associate professor at UC Santa Barbara, now at Oregon State University. "We had some evidence of a cloud cover gradient from the coast to inland, based on our own observations and our weather station data, but the satellite data -- from NOAA and NASA satellites -- really allowed us to quantify this gradient across the western half of the island and in particular at our two study sites," said Still.

Still said that the authors believe this study is unique in linking clouds to soil microbial activity. "While most previous research on fog and ecosystems has focused on its role in plant-water relations -- such as the well-known linkages between fog and coast Redwoods -- we show that soil microbial activity and metabolism in these coastal ecosystems may be very dependent on the light but frequent fog drip that occurs during the rainless summer months," said Still. The study is also unique in linking fog and low clouds to the carbon cycle of a coastal ecosystem, including its impact on tree growth and soil respiration.

"What we found was that there are two major effects of the clouds," said Carbone. "One is shading, which keeps the temperatures cooler and the soil moisture higher. The other is fog drip, which is a water input into the soil."

The soil moisture content was not depleted as rapidly where the trees were under more cloud cover, and thus they were able to grow longer into the dry season. Water pulses from fog drip immediately stimulated microbes in the litter and soil below, but did not directly enhance pine tree activity. The microbial activity releases carbon dioxide into the atmosphere.

"This study provides us with a greater understanding of how fog and the low coastal clouds which Californians commonly call 'the marine layer' affect plant growth and the activities of microorganisms in the soil," said John Randall, scientist with The Nature Conservancy, which owns and operates Santa Cruz Island in cooperation with the National Park Service and the University of California. "Their findings of the importance of fog and low clouds in influencing plant growth and survival and microbial metabolism in the soil will help us understand how changes in coastal fogs and low clouds that may accompany climate change will affect the forests and soils on Santa Cruz Island, other islands off the coast of California and Mexico, and all along the coast of the adjacent mainland."

The work on Santa Cruz Island, conducted in cooperation with The Nature Conservancy, was funded by grants from the Andrew Mellon Foundation and the Kearney Foundation of Soil Science. The NOAA Climate and Global Change Postdoctoral Fellowship and the National Center for Ecological Analysis and Synthesis have supported Carbone.

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Story Source:

The above story is reprinted from materials provided by University of California - Santa Barbara.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Mariah S. Carbone, A. Park Williams, Anthony R. Ambrose, Claudia M. Boot, Eliza S. Bradley, Todd E. Dawson, Sean M. Schaeffer, Joshua P. Schimel, Christopher J. Still. Cloud shading and fog drip influence the metabolism of a coastal pine ecosystem. Global Change Biology, 2012; DOI: 10.1111/gcb.12054

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/eBXm1ty__uI/121128122039.htm

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David_Halperin: For-Profit College Industry's Phony Pitch to Obama: Now We're BFFs!

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The controversial for-profit college industry, threatened by the Obama administration?s efforts to hold it accountable for a torrent of waste, fraud, and abuse at the expense of students and taxpayers, bet heavily on a Romney and GOP victory in 2012. ?The industry, which gets $32 billion a year from taxpayers and whose biggest players get 86 percent of their revenues from federal funds, gave millions of that money to Republican candidates and Super PACs. This was on top of the tens of millions the industry has spent on lobbying, lawyering, and advertising to defeat the Obama reforms.

So, having bet on the wrong horse, and with its enrollments and revenues already in serious decline, what does the industry say to Obama now??We?re your best friends.

The chief lobbyist for the industry, former Congressman Steve Gunderson, writes in Roll Call:

[T]he president and private for-profit schools have a common mission, and ? neither can succeed without the other?s success.

President Barack Obama received historic levels of support from women, African-Americans, Hispanics and young adults up to age 30. ? This base of political support is the very description of the students served by our private-sector colleges. More than 60 percent of our students are women and about 40 percent are African-American or Hispanic. This link provides an opportunity for us to advance our common interests?.

Considering the legions of working parents, single moms, veterans and underserved citizens who use our schools to bring them closer to a better life, our institutions are part of the vision the president communicated.

OK, the nerve of some people. I?ve heard Gunderson say more than once that the companies who pay his salary ?should be congratulated? for enrolling students of color and other underserved people. But simply signing up students and depositing their federal checks is much, much worse than doing nothing for them if your school does not provide a quality education, a valued degree, or reasonable job placement assistance. Schools should be congratulated if they actually do those things for students.

Sadly, many of the schools that are part of Mr. Gunderson?s trade association, APSCU, do no such thing. They excel at recruiting students with misleading and coercive recruiting tactics. They often fail at everything else, leaving students across the country with insurmountable debt that ruins their lives. Several of them were profiled this week in a report from ABC News. Some reach out to me almost every week, with heartbreaking stories of big for-profit colleges promising them great jobs with big salaries at the end of their studies, but leaving them with weak programs, credits that won?t transfer to traditional colleges, phony career assistance efforts, and degrees that are often considered a joke by employers. They owe tens of thousands, even over $100,000, in student loan debt, debt that can?t be discharged in bankruptcy, and they have no earthly idea how they?ll ever pay it back.

Far from being the friends and empowerers of people of color, women, veterans, and low-income people, many of the big for-profit colleges have been some of their worst predators.

If Gunderson?s trade association truly wants to, as he says, ?work?with [this] administration,? it should begin by dropping its expensive lawsuit aimed at derailing common sense Obama rules that would weed out the worst for-profit programs. It should embrace a genuine reform agenda that protects students against fraud and rewards those schools that truly help students learn and build careers.

This article also appears on Republic Report.

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Source: http://rumorsandnews.com/david_halperin-for-profit-college-industrys-phony-pitch-to-obama-now-were-bffs-3/

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How to Protect Yourself While Shopping Online ... - Yahoo! Finance

Imagine losing your Gmail, Twitter, Apple (AAPL) and Amazon (AMZN) accounts in just one hour. That's what happened to Wired.com senior writer Mat Honan last August. He lost eight years worth of data and tells the tale in the cover story of Wired magazine's December issue.

If this nightmare could happen to an editor at a leading tech publication, what are the odds it could happen to you? It's a sobering question during this holiday season when many of us will be shopping online more than usual.

Related: The Dark Side to Record-Breaking Black Friday

Mat Honan tells The Daily Ticker that most people don't have to worry about online shopping but he warns that there are an "alarming" number of "password leaks."

Honan says passwords now ought to be just one tool in a security arsenal, "not the entire arsenal."

Passwords, coupled with usernames, are the primary way people access their online accounts and protect those accounts from hackers. But Honan says no matter how complex or unique those passwords, they don't offer the protection that's needed.

He recommends this series of do's and don't's for passwords that could help users.

Password Don'ts

  • Don't reuse passwords.
  • Don't use a "dictionary word." That means don't use a single word alone.
  • Don't use words that use "standard number substitutions" such as the number 4 for the letter "a" or the number 5 for the letter "s," which resemble each other. Hackers have tools that can crack those substitutions.
  • Don't use short passwords. They're also easier to crack.

Using the same password for multiple internet sites is the most common mistake people make, says Honan.

Password Do's

  • Enable a second factor of authentication ? in addition to a password ? when offered. An example is the black rectangle that pops up asking you to type in the characters that appear on the page in a bold, dark black swirl. They're annoying and crackable but, writes Honan, "better than nothing." Honan recommends that you use double protection for your primary email and bank accounts and any other crucial online account. He says Gmail and Facebook offer this secondary authentification.
  • Give bogus answers to those security questions that are asked when you forget your password. You may have a harder time remembering this fiction but hackers will also likely have a harder time figuring it out.
  • Scrub your online presence. Hackers can access accounts through your email and billing address information. When available, use opt-out options to get that information removed from online databases. Honan says sites like Spokeo and WhitePages.com offer that option.
  • Create a secure email address to recover passwords that is used for that purpose only and have a username that's not y tied to your name. Honan writes that hackers can more easily access your online information if they know where web sites send your password resets and a second email account can help thwart those efforts.

Related: For Retail, Cyber Monday's Growing in Status--and Dollars

Finally, when shopping online this holiday season Honan recommends using disposable credit card numbers ? which function as virtual prepaid credit cards ? especially when buying gifts from small businesses. Those businesses "tend to be bigger targets" for hackers, says Honan.

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Why Warren Buffett Is Right About Raising Taxes on the Rich

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Source: http://finance.yahoo.com/blogs/daily-ticker/protect-yourself-while-shopping-online-holiday-season-wired-131251561.html

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KRAS and BRAF mutation screening in metastatic colorectal cancer ...

Researchers report that screening for KRAS and BRAF mutations can reduce the cost of anti-EGFR treatment for metastatic colorectal cancer but with a very small reduction in overall survival according to a new study published on November 28 in the Journal of the National Cancer Institute.

Metastatic colorectal cancer patients whose tumors harbor mutations in KRAS (and to a lesser extent, in BRAF) are unlikely to respond to costly anti-EGFR therapies. Screening of patients who are candidates for these therapies for mutations in one of these genes (KRAS) has been recommended, with the goal of providing treatment to those who are likely to benefit from it while avoiding unnecessary costs and harm to those who are not likely to benefit. However, the real-world impact of mutation screening for both KRAS and BRAF is unclear.

To better understand the impact of mutation screening with regard to health outcomes, costs, and value, Ajay S. Behl, Ph.D., M.B.A., of the HealthPartners Research Foundation in Bloomington, Minnesota, and colleagues, performed a cost-effectiveness analysis that took into account the treatments, resection of metastases, and survival for the different types of metastases. They conducted patient-level decision analytic simulation modeling comparing four strategies involving KRAS and BRAF mutation testing to select treatments for metastatic colorectal cancer patients: no anti-EGFR therapy (best supportive care); anti-EGFR therapy without screening; screening for KRAS mutations only (before providing anti-EGFR therapy); and screening for KRAS and BRAF mutations (before providing anti-EGFR therapy).

The researchers found that compared with no anti-EGFR therapy, screening for both KRAS and BRAF mutations showed a very high (ie, unfavorable) incremental cost-effectiveness ratio, meaning it was very costly in relation to its benefits. Compared with anti-EGFR therapy without screening, screening for KRAS mutations saved approximately $7,500 per patient; adding BRAF mutation screening saved another $1023, with little reduction in expected survival.

The authors write, "In general, our results are less supportive of the use of anti-EGFR therapy than previous analyses, and they indicate lower cost savings from KRAS testing than previously reported. Although we cannot confirm that anti-EGFR therapy is a cost-effective use of health care resources, we can affirm that KRAS testing is cost-saving. BRAF testing may offer additional savings."

In an accompanying editorial, Josh J. Carlson, M.P.H., Ph.D., of the Department of Pharmacy, University of Washington, and Scott D. Ramsey, MD, PhD, of the Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, both in Seattle, note two practical points highlighted by the study: that molecular testing is as much about generating cost savings by identifying nonresponders as it is about improving survival by identifying responders, and that good modeling must account for the fact that community practice (as opposed to clinical trials) "is messy." They write, "most importantly, this study of an unusually accurate test raises important issues that should be considered for other molecular tests in other settings."

Journal reference: Journal of the National Cancer Institute

Provided by Journal of the National Cancer Institute

Source: http://medicalxpress.com/news/2012-11-kras-braf-mutation-screening-metastatic.html

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বুধবার, ২৮ নভেম্বর, ২০১২

Taliban, Hizb-e-Islami Representatives Join Peace Forum In Japan

The Islamic Emirate of Afghanistan (the Taliban's shadow government) has confirmed that a Taliban representative joined officials from the Afghan government and Hizb-e-Islami Afghanistan in attending a peace forum in Japan, according to a Pakistani daily.

To read the full report, click here.

YOU MUST BE A JTTM SUBSCRIBER TO VIEW THE FULL REPORT. TO SUBSCRIBE, CLICK HERE.

Source: http://thememriblog.org/urdupashtu/blog_personal/en/42089.htm

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Preventive screening for sudden cardiac death in young athletes debated

ScienceDaily (Nov. 26, 2012) ? While ensuring the safety of high school and college athletes is hardly controversial, the method and associated costs of doing so are hotly debated. Conducting electrocardiographic (ECG) screenings of all young competitive athletes in the United States would cost up to $69 billion over 20 years and save about 4,813 lives, making the cost per life saved over $10 million, according to a study published online November 27 in the Journal of the American College of Cardiology.

A corresponding editorial suggests that this number is inflated and "misleading" and blames the high costs on cultural attitudes and medical policies on preventative medicine in the United States. The issue has been widely debated among experts currently in sports cardiology, a growing field of medicine in the United States. The European Society of Cardiology recommends mandatory ECG screening of all competitive athletes, but the American Heart Association recommends a physical exam and family history questionnaire as a first-line screening, with further examination based on the results of those initial steps.

"While this research focuses on the monetary costs of mandatory ECG screening, it is important to consider the human costs of false positives, which can result in additional potentially unnecessary tests and removal from play of athletes who are not actually at risk," said ACC President William Zoghbi, MD, FACC. "Most in this discussion agree that physicals, thorough family histories, targeted testing with ECG and other modalities when needed, widespread training in CPR, and availability of automated external defibrillators save lives from sudden cardiac arrest."

A 2006 Italian observational study found that mandatory ECG-based screening of athletes implemented by Italian law led, over a 20-year period, to a 89 percent relative risk reduction in sudden cardiac death; however, the absolute risk reduction, the cost and the economic ramifications have not been addressed in this study.

Researchers in the current study established a cost-projection model based on the Italian study to estimate the number of athletes who would need to undergo screening if it were required in the U.S., compute the costs and determine the number of lives that could be saved. The number of screening-eligible athletes was estimated from data provided by the National Collegiate Athletic Association and the National Federation of State High School Associations and diagnostic test costs were determined from Medicare reimbursement rates.

Based on this data, researchers determined that 8.5 million athletes would undergo annual ECG screening over 20 years, with 2 percent ultimately disqualified as a result of follow up screenings each year. That equates to 170 million screening tests and 3.4 million disqualifications over two decades.

The number of athletes disqualified for heart conditions would cause the sudden cardiac death rate to decrease from 4 to 0.43 per 100,000, but the costs would be in the billions. Researchers estimate that 20 years of testing would cost between $51 billion and $69 billion and save about 4,813 lives, which averages to between $10.6 million and $14.4 million per life saved.

Antonio Pelliccia, MD, of the Institute of Sport Medicine and Science in Rome, disagrees with the conclusions of the study. He argues the study overestimates costs because the screenings are part of a preventative program that targets young people who are for the most part healthy, is conducted outside of hospitals and is performed by team physicians, not cardiologists. Screenings would be packaged as a unique medical procedure instead of priced as individual diagnostic tests.

He acknowledges that reimbursement of pre-participation screenings as a preventative medicine program does not currently exist in the Medicare system and this "represents a major obstacle" in implementing ECG-based pre-participation screening.

According to Dr. Pelliccia, in Italy where ECG screening is mandatory for athletes, the cost is about $60 per athlete, including history, physical and 12-lead ECG, which is a price based on an agreement between the Board of Sport Physicians and the Italian government. The National Health System also refunds this fee for low income individuals.

He said the obstacles in the United States are not economic but cultural and "will require a change in the cultural attitude and current medical policy in the United States, where preventative medicine programs are unlikely to be federally supported."

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Story Source:

The above story is reprinted from materials provided by American College of Cardiology, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal References:

  1. Sidney C. Smith, Amy Collins, Roberto Ferrari, David R. Holmes, Susanne Logstrup, Diana Vaca McGhie, Johanna Ralston, Ralph L. Sacco, Hans Stam, Kathryn Taubert, David A. Wood, William A. Zoghbi. Our Time: A Call to Save Preventable Death From Cardiovascular Disease (Heart Disease and Stroke). Journal of the American College of Cardiology, 2012; 60 (22): 2343 DOI: 10.1016/j.jacc.2012.08.962
  2. Antonio Pelliccia. Is the Cost the Reason for Missing the ECG Advantages? Journal of the American College of Cardiology, 2012; 60 (22): 2277 DOI: 10.1016/j.jacc.2012.08.996

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/OIXaR4ewQvU/121126164257.htm

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Fostering Curiosity: Mars Express relays rocky images

ScienceDaily (Nov. 26, 2012) ? For the first time, ESA's Mars orbiter has relayed scientific data from NASA's Curiosity rover on the Red Planet's surface. The data included detailed images of 'Rocknest3' and were received by ESA's deep-space antenna in Australia.

It was a small but significant step in interplanetary cooperation between space agencies.

Early on the morning of 6 October, ESA's Mars Express looked down as it orbited the planet, lining up its lander communication antenna to point at Curiosity far below on the surface.

For 15 minutes, the NASA rover transmitted scientific data up to the ESA satellite. A few hours later, Mars Express slewed to point its high-gain antenna toward Earth and began downlinking the precious information to the European Space Operations Centre in Darmstadt, Germany, via the Agency's 35 m-diameter antenna in New Norcia, Australia.

The data were immediately made available to NASA's Jet Propulsion Laboratory in California for processing and analysis, proving again that NASA's amazing new rover can talk with Europe's veteran Mars orbiter.

Curiosity's ChemCam images Rocknest3

The information included a tremendously interesting image acquired on 4 October by Curiosity's ChemCam Remote Micro-Imager camera.

ChemCam comprises the camera together with a Laser-Induced Breakdown Spectrometer, which fires a laser at targets and analyses the chemical composition of the vaporised material.

The laser zaps areas smaller than 1 mm across on the surface of martian rocks and soils, and then the spectrometer provides information on the minerals and microstructures in the rocks.

"The quality of these images from ChemCam is outstanding, and the mosaic image of the spectrometer analyses has been essential for scientific interpretation of the data," says Sylvestre Maurice, Deputy Principal Investigator for ChemCam at France's Research Institute in Astrophysics and Planetology (IRAP).

"This combination of imaging and analysis has demonstrated its potential for future missions."

ChemCam laser targets

A third image, relayed separately by NASA, indicates the locations of the laser target points on Rocknest3, as seen by the RMI camera.

'Rocknest' is the area where Curiosity stopped for a month to perform its first mobile laboratory analyses on soil scooped from a small sand dune. Rocknest3 was a convenient nearby target where ChemCam made more than 30 observations using 1500 laser shots.

A wide-angle context image was acquired by Curiosity's MastCam and shows Rocknest3 as targeted by ChemCam. Rocknest3 is about 10 x 40 cm, or roughly the size of a shoe box.

Fostering Curiosity -- and others

ESA's Mars orbiter has also relayed data for NASA's other surface missions -- Phoenix, Spirit and Opportunity -- since 2004, and it relayed Curiosity's radio signal during its arrival at Mars last August.

During the Curiosity mission, Mars Express is set to provide additional relay slots, while maintaining its own scientific observation programme, under an ESA-NASA support agreement.

It can also rapidly provide relay services in case of unavailability of NASA's own relay orbiter or if there is a problem on the rover itself.

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Story Source:

The above story is reprinted from materials provided by European Space Agency (ESA).

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/iqKUdE5FOGY/121126130945.htm

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'Fiscal cliff': Can a liberal senator sell entitlement reform to Democrats?

Sen. Dick Durbin, in a speech Tuesday, said progressives cannot stay on the sidelines of the 'fiscal cliff' debate and must be ready to make changes to treasured programs like Medicare.

By David Grant,?Staff writer / November 27, 2012

US Sen. Dick Durbin, D-Ill, addresses supporters of President Barack Obama at the Waukesha, Wis. office of Obama For America, in October.

Charles Auer/The Waukesha Freeman/AP

Enlarge

Sen. Dick Durbin (D) of Illinois, one of Congress?s leading liberals, laid out the progressive case for getting on board with a grand bargain that restructures both American taxing and spending ? including some of the left?s sacred entitlement programs ? in a speech Tuesday at the liberal Center for American Progress in Washington.

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?Progressives cannot afford to stand on the sidelines in this fiscal cliff debate and to deny the obvious,? Senator Durbin said. ?I think we need to be part of this conversation, which means we need to be open to some topics and some issues that are painful and hard for us to talk about.?

His speech comes at a time when liberal organizations, including labor unions and groups representing senior citizens, are running advertisements urging Democratic lawmakers not to make any cuts to entitlement programs, including Medicare and Social Security, in the context of avoiding the ?fiscal cliff.?

The cliff, allowing the economy to endure some $600 billion in higher taxes and lower spending scheduled to hit beginning Jan. 1, would send the US economy back into a recession for the year, congressional budget analysts estimate.

Some Republican lawmakers have shown a willingness to consider the higher tax revenues that President Obama and Democrats seek ? but only if paired with reforms to entitlement programs like Medicare, which already consumes a fifth of the federal budget.

Liberal groups have fought back, leaving progressives like Durbin in a strange spot. His tenure in the trenches negotiating an encompassing framework for cutting America?s debt and deficits in part through entitlement changes stretches back to the original presidential commission on debt in 2010 (whose output became known as the Simpson-Bowles plan) and on through the bipartisan ?Gang of Six? senators who strove to hammer out a compromise plan right up to the November election.

On Tuesday, he argued that liberals risked having their views ignored if they hewed to promises to never touch entitlements or other government programs dear to Democrats.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/6iVnHDOJzLg/Fiscal-cliff-Can-a-liberal-senator-sell-entitlement-reform-to-Democrats

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Source: http://blog.publishedandprofitable.com/2012/11/26/preparing-to-write-market-publish-a-book-in-2013-free-call/

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Republicans oppose Senate vote on UN disability treaty during lame-duck session (Star Tribune)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/266484455?client_source=feed&format=rss

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Rep. Shelley Moore Capito will run for Senate (Washington Post)

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Connecticut upsets No. 19 Louisville 23-20 in 3OTS

LOUISVILLE, Ky. (AP) ? Blidi Wreh-Wilson knew the ball would eventually come his way. The Connecticut cornerback just wanted to make sure he was in the right position to make a play.

Wilson's first interception of the season came in the third overtime Saturday and helped the Huskies upset No. 19 Louisville 23-20.

On third and goal from Connecticut's 5, Louisville quarterback Teddy Bridgewater looked for DeVante Parker in the end zone. But his pass was slightly behind his receiver and Wreh-Wilson, one of the top cornerbacks in the country, read it perfectly to make the pickoff.

Four plays later Chad Christen kicked a 30-yard field goal to give the Huskies (5-6, 2-4 Big East Conference) their second straight win and maintain their bowl hopes.

"I just know in the red zone they like to go back-shoulder on the fade ball and I had the guy across from me," Wreh-Wilson said. "On the play before, they ran a similar route and I played it the same way.

"This time, the ball came to me. I flattened him out and didn't let him go upfield. I pushed him toward the sideline."

Connecticut's victory denied Louisville (9-2, 4-2) a chance to tie first-place Rutgers (9-2, 5-1). The No. 21 Scarlet Knights lost 27-6 to Pittsburgh. The Cardinals will play at Rutgers Thursday night and the winner will earn the Big East's BCS bid.

"It's tough when you lose one like that, the way we battled back to get the game into overtime," Cardinals coach Charlie Strong said.

The Huskies' defense made a 10-0 lead stand for more than three quarters before the Cardinals regrouped in the fourth behind Bridgewater. Although Louisville outgained Connecticut 401-241, the Huskies made the stand they needed at the right time.

"We were just looking for a few points in the second half and weren't able to come up with points in the third and fourth quarters," Connecticut coach Paul Pasqualoni said. "I thought our guys hung in there on pride and with character and how hard they fought in this game.

"We just have to play the overtime. As a coach you just figure out how you can get in position to try and win the game and give the kids a chance to score some points and stop them on defense. We were fortunate here today and we came out ahead in a tough game."

Others played big roles in the Huskies' win.

Johnny McEntee relieved an injured Chandler Whitmer in the fourth quarter and threw a 3-yard touchdown pass to Shakim Phillips in the second OT. Lyle McCombs rushed for 133 yards on 29 carries and Nick Williams scored on a 3-yard run to put the Huskies up 10-0.

Christen gave Connecticut its first lead with a 39-yard field goal in the first quarter.

It was nearly a storybook comeback for Bridgewater, who sustained a broken left wrist on a second-quarter sack by Sio Moore and sat out most of the third quarter. The sophomore returned to lead Louisville's fourth-quarter rally and force overtime with a 6-yard touchdown pass to Parker with 21 seconds remaining in regulation.

Bridgewater finished 30 of 53 passing for 331 yards and two touchdowns. But he was sacked four times along with the game-changing interception.

Louisville, which lost leading rusher Senorise Perry two weeks ago with a torn ACL, gained 27 yards rushing.

"The way we were blocking, no running back could have been a difference-maker," Strong said.

For Connecticut, that was nothing new. The Huskies entered the game with the nation's ninth-ranked defense and was No. 11 against the run at 108 yards allowed per game.

And they applied those strengths early and often against the Cardinals, who had the conference's top scoring offense.

Louisville was outgained 160-88 in the first half while being shut out for the first time since Pittsburgh did it here a year ago. Bridgewater's timing and mechanics looked particularly off with passes either underthrown or overthrown.

His receivers didn't help him by dropping passes, either. One flub by a wide-open Parker on the second drive brought an angry Strong on the field to yell at his players.

"We hurt ourselves a lot," senior center Mario Benavides said. "Typical game when things aren't going your way, you stop yourself."

And while Connecticut's offense wasn't great, the Huskies took advantage of their few opportunities.

After two three-and-out drives, Connecticut moved 51 yards in eight plays to set up Christen's 39-yard field goal. Two drives later it was 10-0 as the Huskies drove 66 yards in 10 plays ending in Williams' 3-yard touchdown run.

The lead stood until Bridgewater's return inspired the Cardinals and the crowd of 45,618 late in the third quarter. After John Wallace's 19-yard field goal early in the fourth, Bridgewater directed a 92-yard, 13-play drive kept alive by a 28-yard pass to Eli Rogers and a 9-yarder to Wright for first down at the Huskies' 26.

A 14-yard pass to Wright and a face mask foul penalty on Connecticut set up first-and-goal at the 6, and Bridgewater found a wide-open Parker in the end zone.

Source: http://news.yahoo.com/connecticut-upsets-no-19-louisville-23-20-3ots-212524811--spt.html

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One killed, 60 hurt in an attack on Egypt's Brotherhood office

CAIRO (Reuters) - A Muslim Brotherhood member was killed and 60 people were injured on Sunday in an attack on the main office of the Brotherhood in the Egyptian Nile Delta town of Damanhour, the website of the Brotherhood's Freedom and Justice Party said.

"Brotherhood member, Islam Fathy Masoud, 15, was killed and 60 were injured after thugs attacked the Muslim Brotherhood's headquarters in Damanhour in the total absence of police forces," the website said

(Reporting by Ali ABdelatti, writing by Yasmine Saleh)

Source: http://news.yahoo.com/one-killed-60-hurt-attack-egypts-brotherhood-office-201405824.html

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What are the charms of a fat bloke?

goo Ranking had a look at the charms of plump guys; I?ll keep my eyes open for the female equivalent, of course!

Demographics

Over the 5th and 6th of October 2012 1,064 members of the goo Research monitor group completed a private internet-based questionnaire. 58.2% of the sample were female, 10.5% in their teens, 13.7% in their twenties, 26.6% in their thirties, 27.6% in their forties, 11.7% in their fifties, and 9.9% aged sixty or older. Note that the score in the results refers to the relative number of votes for each option, not a percentage of the total sample. This question was for the females only.

I cannot think of anything to add to this, so here instead is someone looking fat and gentle?

fat fluffy cat

Ranking result

Q: What are the charms of a plump guy? (Sample size=619, female)

Rank ? Score
1 Gentle disposition 100
2 Tolerant 87.9
3 Easy to feel friendly towards 84.2
4 Feel relaxed when we?re together 62.6
5 Doesn?t leave anything on the plate 57.9
6 Has a cute air 54.2
7 Warm hugs 51.1
8 Would protect me 49.5
9 Not likely to say things about my own body shape 47.9
10 Eats without hesitation 44.2
11 Lovely smile 43.2
12 Unlikely to be unfaithful 40.5
13 He makes me look slim when we walk beside each other 38.9
14 Knows all the good places to eat 33.7
15 Nice and squishy to touch 31.1
Read more on: fat,goo ranking

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    Egypt's Mursi faces judicial revolt over decree

    CAIRO (Reuters) - Egyptian President Mohamed Mursi faced a rebellion from judges who accused him on Saturday of expanding his powers at their expense, deepening a crisis that has triggered violence in the street and exposed the country's deep divisions.

    The Judges' Club, a body representing judges across Egypt, called for a strike during a meeting interrupted with chants demanding the "downfall of the regime" - the rallying cry in the uprising that toppled Hosni Mubarak last year.

    Mursi's political opponents and supporters, representing the divide between newly empowered Islamists and their critics, called for rival demonstrations on Tuesday over a decree that has triggered concern in the West.

    Issued late on Thursday, it marks an effort by Mursi to consolidate his influence after he successfully sidelined Mubarak-era generals in August. The decree defends from judicial review decisions taken by Mursi until a new parliament is elected in a vote expected early next year.

    It also shields the Islamist-dominated assembly writing Egypt's new constitution from a raft of legal challenges that have threatened the body with dissolution, and offers the same protection to the Islamist-controlled upper house of parliament.

    Egypt's highest judicial authority, the Supreme Judicial Council, said the decree was an "unprecedented attack" on the independence of the judiciary. The Judges' Club, meeting in Cairo, called on Mursi to rescind it.

    That demand was echoed by prominent opposition leader Mohamed ElBaradei. "There is no room for dialogue when a dictator imposes the most oppressive, abhorrent measures and then says 'let us split the difference'," he said.

    "I am waiting to see, I hope soon, a very strong statement of condemnation by the U.S., by Europe and by everybody who really cares about human dignity," he said in an interview with Reuters and the Associated Press.

    More than 300 people were injured on Friday as protests against the decree turned violent. There were attacks on at least three offices belonging to the Muslim Brotherhood, the movement that propelled Mursi to power.

    POLARISATION

    Liberal, leftist and socialist parties called a big protest for Tuesday to force Mursi to row back on a move they say has exposed the autocratic impulses of a man once jailed by Mubarak.

    In a sign of the polarization in the country, the Muslim Brotherhood called its own protests that day to support the president's decree.

    Mursi also assigned himself new authority to sack the prosecutor general, who was appointed during the Mubarak era, and appoint a new one. The dismissed prosecutor general, Abdel Maguid Mahmoud, was given a hero's welcome at the Judges' Club.

    In open defiance of Mursi, Ahmed al-Zind, head of the club, introduced Mahmoud by his old title.

    The Mursi administration has defended the decree on the grounds that it aims to speed up a protracted transition from Mubarak's rule to a new system of democratic government.

    Analysts say it reflects the Brotherhood's suspicion towards sections of a judiciary unreformed from Mubarak's days.

    "It aims to sideline Mursi's enemies in the judiciary and ultimately to impose and head off any legal challenges to the constitution," said Elijah Zarwan, a fellow with The European Council on Foreign Relations.

    "We are in a situation now where both sides are escalating and its getting harder and harder to see how either side can gracefully climb down."

    ADVISOR TO MURSI QUITS

    Following a day of violence in Cairo, Alexandria, Port Said and Suez, the smell of tear gas hung over the capital's Tahrir Square, the epicentre of the uprising that toppled Mubarak in 2011 and the stage for more protests on Friday.

    Youths clashed sporadically with police near the square, where activists camped out for a second day on Saturday, setting up makeshift barricades to keep out traffic.

    Al-Masry Al-Youm, one of Egypt's most widely read dailies, hailed Friday's protest as "The November 23 Intifada", invoking the Arabic word for uprising.

    But the ultra-orthodox Salafi Islamist groups that have been pushing for tighter application of Islamic law in the new constitution have rallied behind Mursi's decree.

    The Nour Party, one such group, stated its support for the Mursi decree. Al-Gama'a al-Islamiya, which carried arms against the state in the 1990s, said it would save the revolution from what it described as remnants of the Mubarak regime.

    Samir Morkos, a Christian assistant to Mursi, had told the president he wanted to resign, said Yasser Ali, Mursi's spokesman. Speaking to the London-based Asharq Al-Awsat newspaper, Morkos said: "I refuse to continue in the shadow of republican decisions that obstruct the democratic transition".

    Mursi's decree has been criticized by Western states that earlier this week were full of praise for his role in mediating an end to the eight-day war between Israel and Palestinians.

    "The decisions and declarations announced on November 22 raise concerns for many Egyptians and for the international community," State Department spokeswoman Victoria Nuland said.

    The European Union urged Mursi to respect the democratic process.

    (Additional reporting by Omar Fahmy, Marwa Awad, Edmund Blair and Shaimaa Fayed and Reuters TV; Editing by Jon Hemming)

    Source: http://news.yahoo.com/egypts-mursi-faces-judicial-revolt-over-decree-092225969.html

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    Facebook and volatile market still chill IPOs

    Making a killing on initial public offerings used to be easy.

    At the peak of the technology boom, little more than a decade ago, a plentiful supply of companies vied to sell stock on the exchanges, and investors were assured mouthwatering returns.

    These days, the deals are fewer and the returns more modest.

    Companies are set to raise more than $45 billion through IPOs this year ? the most since 2007, according to data provider Dealogic. But if you scratch the surface, there are signs that the market is less healthy than it appears.

    Almost a third of the money raised in IPOs this year came from one deal, Facebook's $16 billion offering in May, and the number of companies taking themselves public may end at a three-year low.

    The pipeline, or backlog, of companies planning to sell stock is also thinning.

    "It's a reflection of the psychology of the market today. It's not strong. It's moderate to weak," says Rob Lutts, chief investment officer at Cabot Money Management in Salem, Mass.

    While 437 companies have filed for an IPO this year, 178 have withdrawn or postponed their planned listings, Dealogic data show.

    The state of the IPO market matters beyond Wall Street. Besides giving investors the chance to buy into fast-growing parts of the market, offerings give companies the money to expand and hire workers.

    Scott Cutler, head of global listings at NYSE Euronext, which runs the New York Stock Exchange, estimates that more than 90 percent of a public company's employee growth comes after it has listed on an exchange.

    IPO activity is dictated largely by the health of the overall stock market. Falling markets discouraging companies from going public.

    The Standard & Poor's 500 is up 11 percent this year, but the advance has been punctuated by sharp declines when investors fretted about European debt, the election and, now, a looming "cliff" of tax increases and government spending cuts.

    "The general market has been real choppy this year. It really has," says Sal Morreale, an institutional salesman at Cantor Fitzgerald in Los Angeles who tracks offerings.

    Facebook's calamitous market debut also put the brakes on IPOs.

    The social networking site's offering was the most keenly anticipated market debut at least since Google's in 2004. But concerns about revenue from smartphone users spooked investors, and the offering was plagued by technical glitches.

    The stock was priced at $38 and fell almost immediately, dropping as low as $17.55 on Sept. 4. The negative publicity helped shutter the IPO market for more than a month until EQT Midstream Partners, an energy company, sold stock June 16. Companies including American Tire Distributors and Crosair, a computer memory company, were among those withdrawing their IPOs.

    "That deal has become a textbook case of how not to do a deal," says Quincy Krosby, a market strategist with Newark, N.J.-based Prudential Financial. "That IPO really chastened investors."

    The backlog of companies planning IPOs fell to 39 in November, according to data from Ipreo, a market analysis company firm. That is the fewest since August 2009, just after the recession. The tally has been declining steadily since September 2011.

    NYSE's Cutler says that much of the decline is because of a law passed in April designed to make it easier for companies to attract funding. They can confidentially notify regulators of their intention to seek a listing.

    Cutler says that if the business environment remains stable, the pace of IPO filling will be "slightly up" next year as companies become more familiar with the law.

    The law allows companies to avoid disclosing competitively sensitive information and come to the market at much shorter notice. Ultimately, it will encourage more companies to seek listings, Cutler says.

    Despite Facebook's high-profile slump, most companies have left something on the table for investors.

    The average return for IPOs this year has been 11 percent, according to Dealogic data. That's less than the average 88 percent one-year return that investors garnered in 1999, but roughly in line with the broader market.

    Among the best debuts: Guidewire Software, a provider of software for the insurance industry, and Nationstar Mortgage Holdings, a Texas mortgage provider and servicer, according to data from IPO investment advisory firm Renaissance Capital.

    Investors that bought Guidewire's stock at $13 at its market debut in January have seen it rise to almost $30, while Nationstar's stock has almost doubled from $14 to $27.35.

    There are some advantages to a slow IPO market, says Lutts of Cabot Money Management. When demand is low, only the best companies are able to attract enough demand to list on the exchanges, raising the quality of companies coming to the market. And it can be an indicator that the broader market is oversold and thus offers some bargains.

    "When we're frothy, everything is coming at a premium," Lutts says. "I'm interested in equities today because of a weak IPO market."

    Source: http://news.yahoo.com/facebook-volatile-market-still-chill-ipos-164956367--finance.html

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