মঙ্গলবার, ২ এপ্রিল, ২০১৩

Drug maker Novartis loses India patent battle

FILE - In this Thursday, Feb. 9, 2012 file photo, a pharmacist works in a lab where medicines are being produced at a Cipla manufacturing unit on the outskirts of Mumbai, India. A lawyer for healthcare activists says India's Supreme Court has rejected drug maker Novartis AG' right to patent a new version of a lifesaving cancer drug. The landmark ruling today is a victory for India's (Canadian) $26 billion generic drug industry that provides cheap medicines to millions around the world. Novartis has fought a legal battle in India since 2006 for a fresh patent for its cancer drug Glivec. Cipla makes a generic version of Glivec. (AP Photo/Rafiq Maqbool, File)

FILE - In this Thursday, Feb. 9, 2012 file photo, a pharmacist works in a lab where medicines are being produced at a Cipla manufacturing unit on the outskirts of Mumbai, India. A lawyer for healthcare activists says India's Supreme Court has rejected drug maker Novartis AG' right to patent a new version of a lifesaving cancer drug. The landmark ruling today is a victory for India's (Canadian) $26 billion generic drug industry that provides cheap medicines to millions around the world. Novartis has fought a legal battle in India since 2006 for a fresh patent for its cancer drug Glivec. Cipla makes a generic version of Glivec. (AP Photo/Rafiq Maqbool, File)

A billboard for wholesale rate of cancer medicines is seen outside a chemist store, in New Delhi, India, Monday, April 1, 2013. India's Supreme Court on Monday rejected drug maker Novartis AG's attempt to patent a new version of a cancer drug Glivec in a landmark decision that healthcare activists say ensures poor patients around the world will get continued access to cheap versions of lifesaving medicines. (AP Photo/Manish Swarup)

FILE - In this Monday, Jan. 29, 2007 file photo, Indian police officers block demonstrators protesting against drug manufacturer Novartis' case against Indian government on drug patents in New Delhi, India. A lawyer for healthcare activists says India's Supreme Court has rejected drug maker Novartis AG' right to patent a new version of a lifesaving cancer drug. The landmark ruling Monday, April 1, 2013 is a victory for India's $26 billion generic drug industry that provides cheap medicines to millions around the world. Novartis has fought a legal battle in India since 2006 for a fresh patent for its cancer drug Glivec. (AP Photo/Saurabh Das, File)

FILE - In this Thursday, Feb. 9, 2012 file photo, a man walks past the Cipla manufacturing unit on the outskirts of Mumbai, India. India's Supreme Court on Monday rejected drug maker Novartis AG's attempt to patent a new version of a cancer drug in a landmark decision that healthcare activists say ensures poor patients around the world will get continued access to cheap versions of lifesaving medicines. Novartis had argued that it needed a new patent to protect its investment in the cancer drug Glivec, while activists said the company was trying to use loopholes to make more money out of a drug whose patent had expired. Cipla makes a generic version of Glivec. (AP Photo/Rafiq Maqbool, File)

NEW DELHI (AP) ? India's Supreme Court on Monday rejected drug maker Novartis AG's attempt to patent an updated version of a cancer drug in a landmark decision that health activists say ensures poor patients around the world will get continued access to cheap versions of lifesaving medicines.

Novartis had argued that it needed a patent to protect its investment in the cancer drug Glivec, while activists said the drug did not merit intellectual property protection in India because it was not a new medicine. In response to the ruling, Novartis said it would not invest in drug research in India.

The court's decision has global significance since India's $26 billion generic drug industry, which supplies much of the cheap medicine used in the developing world, could be stunted if Indian law allowed global drug companies to extend the lifespan of patents by making minor changes to medicines.

Once a drug's patent expires, generic manufacturers can legally produce it. They are able to make drugs at a fraction of the original manufacturer's cost because they don't carry out the expensive research and development.

Pratibha Singh, a lawyer for the Indian generic drug manufacturer Cipla, which makes a version of Glivec for less than a tenth of the original drug's selling price, said the court ruled that a patent could only be given to a new drug, and not to those which are only slightly different from the original.

"Patents will be given only for genuine inventions, and repetitive patents will not be given for minor tweaks to an existing drug," Singh told reporters outside the court.

Novartis called the ruling a "setback for patients," and said patent protection is crucial to fostering investment in research to develop new and better drugs.

Ranjit Shahani, the vice chairman and managing director of Novartis India, said the ruling "will hinder medical progress for diseases without effective treatment options."

He said the court's decision made India an even less attractive country for major investments by international pharmaceutical companies.

"Novartis will not invest in drug research in India. Not only Novartis, I don't think any global company is planning to research in India," he said.

The Swiss pharmaceutical giant has fought a legal battle in India since 2006 to patent a new version of Glivec, which is mainly used to treat leukemia and is known as Gleevec outside India and Europe. The earlier version of Glivec did not have an Indian patent because its development far predated the country's 2005 patent law. Novartis said Glivec is patented in nearly 40 other countries.

India's patent office rejected the company's patent application, arguing the drug was not a new medicine but an amended version of its earlier product. The patent authority cited a provision in the 2005 patent law aimed at preventing companies from getting fresh patents for making only minor changes to existing medicines ? a practice known as "evergreening."

Novartis appealed, arguing the drug was a more easily absorbed version of Glivec and that it qualified for a patent.

Anand Grover, a lawyer for the Cancer Patients Aid Association, which led the legal fight against Novartis, said the ruling Monday prevented the watering down of India's patent laws.

"This is a very good day for cancer patients. It's the news we have been waiting for for seven long years," he said.

Aid groups, including Medicins Sans Frontieres, have opposed Novartis' case, fearing that a victory for the Swiss drugmaker would limit access to important medicines for millions of poor people around the world.

Glivec, used in treating chronic myeloid leukemia and some other cancers, costs about $2,600 a month. Its generic version was available in India for around $175 per month.

"The difference in price was huge. The generic version makes it affordable to so many more poor people, not just in India, but across the world," said Y.K. Sapru, of the Mumbai-based cancer patients association.

"For cancer sufferers, this ruling will mean the difference between life and death. Because the price at which it was available, and considering it's the only lifesaving drug for chronic myeloid cancer patients, this decision will make a huge difference," Sapru said.

Leena Menghaney of Medicins Sans Frontieres said India would continue to grant patents on new medicines.

"This doesn't mean that no patents will be granted. Patents will continue to be granted by India, but definitely the abusive practice of getting many patents on one drug will be stopped," Menghaney said.

The judgment would ensure that the prices of lifesaving drugs would come down as many more companies would produce generic versions.

"We've seen this happening with HIV medicines, where the cost of HIV treatment has come down from $10,000 to $150 per year. Cancer treatment costs have come down by 97 percent in the case of many cancer drugs," she said.

"This decision is incredibly important. The Supreme Court decision will save a lot of lives in the coming decades," Menghaney said.

___

AP writer Kay Johnson contributed to this story from Mumbai, India.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-01-India-Patent%20Battle/id-71f81996771a408dbdaa97724d1f7822

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সোমবার, ১ এপ্রিল, ২০১৩

Nicole Lero Technological innovation Choosing a Mobile phone ...

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Source: http://www.onlinekredite-direkt.de/nicole-lero-technological-innovation-choosing-a-mobile-phone-supplier/

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New drug target companion prognostic test for hormone therapy resistance

Apr. 1, 2013 ? A team of international cancer researchers led by Dr. Mathieu Lupien at the Princess Margaret Cancer Centre, University Health Network, has identified the signalling pathway that is over-activated in estrogen receptor (ER)-positive breast cancer cells that are resistant to hormone therapies such as tamoxifen, aromatase inhibitors or fulvestrant.

Resistance to hormone therapy is reported in almost half of ER-positive breast cancer patients and no cure is currently available. The fact that the pathway, called Notch, is a drug target creates hope for a new therapy.

The findings, published online today in the Proceedings of the National Academy of Sciences, "provide a new therapeutic target against hormone therapy-resistant breast cancers and a companion test to identify tumours that would become resistant" says Dr. Lupien, a scientist at the Ontario Cancer Institute, the research arm of the cancer centre, and an Assistant Professor in the Department of Medial Biophysics, University of Toronto. He specializes in epigenetics of hormone-dependent cancers -- the study of non-genetic determinants of cellular identity that can also be altered to initiate or modify disease.

"In studying the epigenetics of hormone therapy resistance, we discovered that breast cancer cells behave like a chameleon. Indeed, as the chameleon changes its skin colour to camouflage itself and evade predators," says Dr. Lupien, "breast cancer cells change the appearance of their DNA through epigenetics to evade, in this case, hormone therapy." In so doing, hormone therapy-resistant breast cancer cells highlight regions of their DNA related to the Notch pathway.

At the molecular level, the research team characterized the epigenetic appearances of the DNA of drug-resistant and drug-responsive breast cancer cells. The team discovered that the Notch signaling pathway plays the predominant role in drug-resistant breast cancer cells even if cells remain positive for ER.

"This is a highly promising discovery that could rapidly translate in the clinic. Drugs against the Notch pathway are available." says Dr. Lupien. The key will be to test the efficacy of these drugs against hormone therapy resistance in breast cancer.

The research was funded by the National Cancer Institute, the American Cancer Society and the Ontario Institute for Cancer Research. Dr. Lupien's research is also supported by The Princess Margaret Cancer Foundation.

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Journal Reference:

  1. Luca Magnani, Alexander Stoeck, Xiaoyang Zhang, Andr?s L?nczky, Anne C. Mirabella, Tian-Li Wang, Bal?zs Gyorffy, and Mathieu Lupien. Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1219992110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/pUzj0i7pl44/130401151035.htm

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Toy model of Jabba The Hutt's palace resembles a mosque, group says

Lego

Birol Kilic, chairman of the Turkish Cultural Association of Austria, says the Lego play set modeled on the Jabba The Hutt alien's fictional home was culturally insensitive.

By Carlo Angerer, Producer, NBC News

MUNICH ? Danish toy maker Lego plans to stop selling a model of the ?palace? of slug-like Star Wars character Jabba The Hutt after complaints that it resembles a revered mosque, according to a group that raised the grievance.

Birol Kilic, chairman of the Turkish Cultural Association of Austria, said Monday the play set modeled on the obese alien?s fictional home was culturally insensitive.

Photo by Julian Finney / Getty Images

Birol Kilic, chairman of the Turkish Cultural Association of Austria, said the Lego version of Jabba The Hutt's palace resembles Istanbul's Hagia Sophia, a historic mosque that became a model for other centers of Islam and is now a museum.

?This does not belong in?children?s bedrooms,? he said. ?And the minaret-like tower features machine guns. Children will become insensitive to violence and other cultures.?

After a meeting between his organization and the company last week in Munich, Germany, Lego promised to stop selling the play set, Kilic said.

Lego posted on Twitter Monday that it has always intended to stop selling the item at the end of the year. ?We only keep a product in the assortment for a few years and it was scheduled to exit in 2013 from launch,? the tweet said.

However, there was no mention of those original plans in a January press release which said: ?The LEGO Group regrets that the product has caused the members of the Turkish cultural community to interpret it wrongly.?

Roar Trangb?k, a Lego spokesman, on Monday denied that the group had anything to do with their decision.

?The decision to terminate this particular product is not based on any dialogue with the mentioned community,"?Trangb?k said. "We regret the misinterpretation but we fully stand behind the product.?

Trangb?k also said that it is the company's policy not to design models that depict religious structures.?

The Danish toy giant has in recent years made building sets modeled on hit movies including Harry Potter, Indiana Jones, and Star Wars.

In the 1983 science-fiction blockbuster ?Return of the Jedi?, Jabba uses Princess Leia as his slave at the palace.

Lego

Birol Kilic, chairman of the Turkish Cultural Association of Austria, says the Lego play set modeled on the Jabba the Hutt alien's fictional home was culturally insensitive.

Kilic believed that the Lego version, aimed at 9- to 14-year-olds, resembles Istanbul?s Hagia Sophia, a historic mosque that became a model for other centers of Islam and is now a museum in the Turkish city.

Kilic said his organization was notified of the issue by an outraged Austrian father, whose sister had given the Lego set to his son last Christmas. The father returned the toy to the store, Kilic said, and the Turkish Cultural Association petitioned Lego to drop the play set from its line-up.

Kilic said the issue was not merely cultural, but also a reminder that parents should be more thoughtful about what toys their kids play with.

?We?re not the Taliban of Vienna,? he said of his independent, Vienna-based organization with about 700 members, ?but we do give thought to our country and our continent.?

?

This story was originally published on

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Argentina challenges U.S. court with bond plan

By Nate Raymond and Hugh Bronstein

NEW YORK/BUENOS AIRES (Reuters) - Argentina challenged a U.S. court over the weekend by proposing that "holdout" bond investors be repaid only about one sixth the money federal judges hearing the case say they are owed, setting the stage for a legal showdown in New York.

The terms offered by Argentina are the same as those accepted by bondholders who chose to participate in the country's 2010 sovereign bond restructuring. The holdouts rejected that restructuring and are holding out for full repayment.

Aside from the implications the case has for Argentina's finances, it could also have wide ramifications for the way future sovereign restructurings are carried around the world.

Argentina defaulted on $100 billion in sovereign debt in 2002 at the height of a financial crisis in Latin America's third largest economy. The bonds now under dispute were issued in New York, which is why the case is being heard in U.S. court.

Elliott Management affiliate NML Capital Ltd, one of the lead plaintiffs, has said that it will not accept 2010 terms They and other holdouts are sure to argue that Argentina's proposal does not respond to the court's request.

"The court said 'You owe the holdouts $1.3 billion. Tell us how you are going to pay that to them,'" said Josh Rosner, managing director at research firm Graham Fisher & Co in New York.

"Instead of answering how they will pay the full amount, Argentina responded with a plan for paying a much smaller amount," he said. "Argentina is flirting with technical default, which would take a serious toll its economy."

The specter of technical defaults comes from the fact that a U.S. District Court in New York has said that until the holdouts start getting paid, Argentina cannot make payments to holders of the restructured bonds.

Elliott stands currently to receive $720 million from Argentina following a New York judge's order in November, according to Argentina.

But the bonds NML could take had a market value of just $186.8 million before a major decision in the case last October favoring the holdouts, or $120.6 million as of March 1, the filing said. Argentina estimates NML paid about $48.7 million in 2008 for its stake in the bonds.

"The Republic is prepared to fulfill the terms of this proposal promptly upon Order by the Court by submitting a bill to Congress that ensures its timely implementation," Jonathan Blackman, Argentina's U.S. lawyer, wrote.

Around 92 percent of Argentina's defaulted bonds were restructured in 2005 and 2010, with bondholders receiving 25 cents to 29 cents on the dollar.

But holdouts led by NML Capital and Aurelius Capital Management have fought for years for full payment. Argentina calls these funds "vultures."

In October, the 2nd Circuit upheld a trial judge's ruling by finding Argentina had violated a so-called pari passu clause in its bond documents requiring it to treat creditors equally.

U.S. District Judge Thomas Griesa in Manhattan subsequently ordered Argentina in November to pay the $1.33 billion owed to the bondholders into an escrow account by the time of its next interest payment to holders of the exchanged debt.

The 2nd Circuit heard an appeal of that order on February 27. Two days later, it directed Argentina to provide details of "the precise terms of any alternative payment formula and schedule to which it is prepared to commit."

BOND OPTIONS

In its 22-page submission late on Friday, Argentina said that under a so-called par bond option, the bondholders would receive new bonds due in 2038 with the same nominal face value of their current bonds. They would pay 2.5 percent to 5.25 percent a year, Argentina said.

Bondholders would also receive an immediate cash payment similar to what it provided under the 2010 debt swap, Argentina said. And they would receive derivative instruments that provide payments when the country's gross domestic product exceeds 3 percent a year.

The par option is restricted to small investors, unlike the discount option, the more applicable fit for big investors like NML and Aurelius.

Under the discount proposal, holdouts could receive new discount bonds due in 2033 that pay 8.28 percent annually. Argentina said the holdouts would also receive past due interest since 2003 in the form of bonds due in 2017 paying 8.75 percent a year, and GDP-linked derivative units.

Blackman, Argentina's lawyer, wrote that the proposal, unlike what he called the "100 cents on the dollar immediately" formula Griesa adopted, "is consistent with the pari passu clause, longstanding principles of equity, and the Republic's capacity to pay."

It was unclear on Saturday how the court might view Argentina's proposals. The same three-judge panel had said in October, though, that the holdouts "were completely within their rights" to reject prior debt swap offers.

Euginio Bruno, a lawyer and bond restructuring expert with the law firm Estudio Garrido Abogados in Buenos Aires, said the government's Friday proposal "was within expectations, considering the legal constraints on offering anything better than the terms of the 2010 restructuring."

Argentina has a "lock law" that keeps new governments from improving the terms of previous restructurings.

Earlier in the week, the holdouts scored a victory over Argentina when the 2nd Circuit denied a full court review of its October ruling on the equal treatment provision.

The United States had backed Argentina in seeking the review, contending the 2nd Circuit's decision ran "counter to longstanding U.S. efforts to promote orderly restructuring of sovereign debt.

Argentina and holders of its restructured bonds say granting the holdouts 100 cents on the dollar could complicate future sovereign restructurings around the world.

Argentine Vice President Amado Boudou repeated on Saturday that Argentina would continue repaying investors who participated in the restructuring no matter how the U.S. court case is resolved.

"One way or another, Argentina will pay," he said.

The case is NML Capital Ltd et al v. Republic of Argentina, 2nd U.S. Circuit Court of Appeals, No. 12-105.

(Reporting by Nate Raymond; Additional reporting by Helen Popper, Alejandro Lifschitz and Guido Nejamkis in Buenos Aires; Editing by Todd Eastham, Will Dunham and Eric Beech)

Source: http://news.yahoo.com/argentina-challenges-u-court-bond-plan-011959470--sector.html

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Health Consumers Don't Give Back Online

People consulting the Internet for health information and advice take what's presented, but rarely give back by posting their own reviews or experiences, new research finds.

This pattern could be skewing the "wisdom of the crowds" about doctors, hospitals and treatment options, said study researcher Rosemary Thackeray of Brigham Young University.

"If more people are contributing to the dialogue, we have maybe better information," Thackeray told LiveScience. "Versus with fewer people, it might be less reliable, more biased."

An estimated 60 percent of people go online looking for health information, and social media is a part of that picture. Social sites include not just the big names like Facebook and Twitter, Thackeray said, but forums, discussion boards and health-specific sites such as PatientsLikeMe. [Read More: Health Insurance Reviews]

Thackeray and her colleagues analyzed data from the 2010 Health Tracking Survey, part of the Pew Internet & American Life Project. As part of the telephone survey, 1,745 adults who said they look up health information online answered questions about the sort of information they sought and posted.

The results revealed that 41 percent consulted consumer reviews of doctors, hospitals and treatments, and 32 percent used social media as part of their research. But only 10 percent posted health-care reviews of their own, and 15 percent posted comments, questions or information in response to others' queries.

"People were consuming information a lot more than they were actually contributing to the dialogue," Thackeray said.

Women were more likely than men to go online looking for health information, which is not surprising, as women tend to be the health-care decision makers in families, Thackeray said. Higher-income people, younger individuals and urban or suburban dwellers were also more likely than poorer, older and rural groups to go online. People with a regular health-care provider and health insurance were also more likely to seek health information online, probably because they have more health-care choices, Thackeray said.

"Some of those demographics mirror who is actually using social media anyway, so you're not finding a lot of older people posting online or consulting online even though they have more health conditions," she said.

Finally, people with chronic diseases were twice as likely as those without to seek health information online. The findings appear online in the Journal of Medical Internet Research.

Inaccurate and biased information is always a concern online, Thackeray said, but there are advantages to seeking out social media input about health ? and reasons to encourage more people to contribute.

"Take what you find online from family and friends, combine that with what you know from your health-care provider," she said. "Together, with all that information, you can become a more informed health-care consumer and make the best decisions for your health."

Follow Stephanie Pappas on Twitter?and Google+. Follow us @livescience, Facebook?& Google+. Original article on LiveScience.com.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/health-consumers-dont-back-online-133949323.html

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Nextdoor Hits 10K Neighborhoods, Gets Me To Stop Running At Night

lost catAfter I had been running at night for more than a decade, a relatively under-the-radar startup called Nextdoor got me to start running during the day. Almost nobody likes to exercise, and for many, overcoming the motivational hump of putting on your shoes and gym clothes can be trying on even the best of days. One evening late in January I had finally overcome this initial barrier to entry, and was just about to stop blogging to do my usual 30-minute nightly sprint when I got the email. “Woman robbed at gunpoint in Dogpatch, San Francisco” the subject line screamed. Unlike many of the emails I constantly receive, this was highly relevant to me, especially because, upon further inspection, the robbery had happened one block from my house. Until this email, I hadn’t given too much thought to Nextdoor , a service that I signed up for at the Allen & Co conference last summer, where co-founder Nirav Tolia had given a talk about the local social network. The company started out as Fanbase in 2009, and was an attempt to create a user-generated content version of ESPN. Founders Tolia and Sarah Leary decided to pivot around May of 2010, and spent the next four to five months testing out different ideas. Fanbase officially pivoted to Nextdoor in September of 2010, starting out its pilot in Lorelei, a neighborhood in Menlo Park. Now a Facebook for your neighborhood, about half the Fanbase funding ended up carrying over, and Tolia and Leary ended up raising an additional $40.2 million for the new Nextdoor product. Initially enthusiastic, I had also invited my neighbors to use the platform, which had resulted in a de facto neighborhood support group (including the services of a pet psychic) when their adventurous cat Kiki went missing. I wrote a post about it for TechCrunch and then sort of forgot about it, rarely logging on to peruse the listings of free stuff and garage sales. Well I was certainly giving the service some thought now: “What if I had been that woman who was robbed?”"What if I had ventured out of my house just 15 minutes earlier?” I was still in my gym clothes, after so much effort, and feeling antsy from my day of work. Worse, I was now worried about a random stranger I had only heard about through the Internet, and I still needed a

Source: http://feedproxy.google.com/~r/Techcrunch/~3/Xv9XgjwdzKs/

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